The mouse ageing atlas: why different tissues age differently

What the research found

The Tabula Muris Senis project profiled cells across 23 mouse tissues and organs over the lifespan. It found age-associated changes within cell types and changes in the mix of cells within tissues. The atlas showed how several recognised features of ageing appear differently across biological contexts. A whole organism therefore cannot be understood through one cell type or one measurement alone.

Where the evidence stops

This is a mouse resource. Associations in a cell atlas do not establish the cause of ageing or identify a safe intervention for an individual person.

The private-client perspective

Personalisation should respect the complexity of the person being assessed. A high-level score can be convenient, but the underlying clinical question may concern cardiovascular risk, muscle function, cognition or recovery. Those questions require different measurements and expertise. A coordinated programme should explain why each assessment was selected, how it is interpreted and when it should be repeated.

Read the source

1. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. (2020-07-15)

An independent editorial synthesis of published research, not an original NoahThera study or a personal medical recommendation. Evidence stages are identified above; cited researchers and institutions are not represented as NoahThera partners.